Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing
articles matching survival — open any to read the full text,
or download the PDF or XML.
Apr 2018
Dongye LiCorresponding author
Heart failure(HF) is a disease with high morbility and mortality. The benefits of current pharmacological and device therapy for survival outcomes of patients with HF are limited. Gene therapy represents a novel promising strategy in treating HF, as it can theoretically normalize the aberrantly expr…
Feb 2018
Jincheng ZengCorresponding author
Gastric cancer is one of the most common types of cancer in the world, usually diagnosed at an advanced stage. Despite the advances in specific anticancer agents' development, the survival rates remain modest, even in early stages. HER2 overexpression was identified on 15% - 20% of gastric cancer pa…
Dec 2017 DOI 10.14302/issn.2576-9359.jot-17-1807
Ryan J. SchuttCorresponding author
Purpose Intra-operative insults may subject living kidney transplants to poor outcomes. Therefore, we investigated whether intra-operative recipient and donor hemodynamics could act as predictors of delayed graft function and subsequent outcomes. Materials and Methods Living kidney donors and recipi…
Dec 2017 DOI 10.14302/issn.2997-2086.jfs-17-1846
Ruchi AminCorresponding author
Introduction: Data support the use of both ultrasound (US) and magnetic resonance imaging (MRI) in the prenatal prognostication of congenital diaphragmatic hernia (CDH). The aim of this study was to examine our experience and learning curve with both of these diagnostic tools in the setting of a new…
Nov 2017 DOI 10.14302/issn.2471-2175.jdrt-17-1760
Madhuri BhandaruCorresponding author
Metastatic melanoma is a very deadly type of skin cancer with poor prognosis and low 5-year survival rates. Until recently, patients with metastatic melanoma had very few treatment options, which only included dacarbazine and aldesleukin. In 2011, the first checkpoint blocker, ipilimumab was approve…
Nov 2017 DOI 10.14302/issn.2372-6601.jhor-17-1761
Gitte Lee MortensenCorresponding author
With the introduction of tyrosine kinase inhibitors (TKI), patients with chronic myeloid leukemia (CML) have obtained survival rates close to normal. It may appear paradoxical, then, that medication adherence is suboptimal in some health care settings. As the first of its kind, this study aimed to e…
Aug 2017 DOI 10.14302/issn.2324-7339.jcrhap-17-1430
Hellen MyezwaCorresponding author
HIV and AIDS remains a major health problem in South Africa even after two decades since the introduction of antiretroviral therapy. Long term survival with HIV is associated with new health related issues and a risk of functional limitation/disability. The aim of this study was to assess the impact…
Aug 2017 DOI 10.14302/issn.2470-5020.jnrt-17-1530
Robert SusloCorresponding author
It is crucial for the society, the government and the medical community to retrieve the full and reliable statistical information on malignant brain neoplasms (C71-C71.9 ICD-10) to adjust the medical financing, staff and equipment properly. In order to retrieve information useful for public health p…
Jul 2017 DOI 10.14302/issn.2326-0793.JPGR-17-1571
Henrique C. P. FigueiredoCorresponding author
Perkinsus marinus is an intracellular parasitic protozoan that is responsible for serious disease epizootics in marine bivalve mollusks worldwide. Despite all available information on P. marinus genomics, more baseline data is required at the proteomic level. Our aim was to study the proteome profil…
May 2017 DOI 10.14302/issn.2470-0436.jos-17-1453
Jie ZhangCorresponding author
Purpose: High intraocular pressure (IOP) is known to result in retinal ganglion cell (RGC) loss, both with chronically raised intraocular pressure (such as with glaucoma) and with acute raises in pressure (due to injury or acute angle closure). Because IOP is often raised during ocular surgery, the…
Mar 2017
Mats RembergerCorresponding author
This article examines how HLA‑DRB1 allele mismatching influences outcomes after hematopoietic stem cell transplantation. It reviews graft‑versus‑host disease risk, engraftment, and survival metrics in the context of donor matching strategies. The findings support careful allele‑level typing to optim…
Jan 2017 DOI 10.14302/issn.2379-8572.joa-16-1399
Muhammet fatih topuzCorresponding author
Aim: The relation between inflammation and cancer has been known since the 19th century. However, investigations on the pathogenesis and pathophysiology of this relation have begun recently. It was demonstrated that increased neutrophil/lymphocyte ratio is a poor prognostic factor in some malignanci…
Oct 2016 DOI 10.14302/issn.2576-182X.jbsc-16-1261
LIEW BOON SENGCorresponding author
Background: Spontaneous primary intracranial hemorrhage or known as intracerebral hypertensive hemorrhage consist of 15 to 20% of all stroke, is one of the major health problems among healthy and productive workforce in any countries. Methods: A retrospective study was conducted in a dedicated Neuro…
Sep 2016 DOI 10.14302/issn.2473-1005.jdoi-16-1137
Surena VahabiCorresponding author
EVC syndrome is a rare autosomal recessive genetic syndrome which its exact prevalence is unknown. The main manifestations of EVC include condro-ectodermal dysplasia, polydactyly, congenital heart defects and tooth and nail hypoplasia, and the survival rate of patients depends on the heart disease.…
Apr 2016 DOI 10.14302/issn.2474-7785.jarh-15-699
Valle Coronado-VázquezCorresponding author
Purpose Hospital readmission of patients with pluripathologies is frequent and costly. This study describes the impact of patients’ pluripathologies, functional capacity and social complexity on readmissions during a 12-month period following hospital discharge. Methods A prospective cohort study. M…
Feb 2016 DOI 10.14302/issn.2572-5424.jgm-15-815
Samah Abd ElhamidCorresponding author
Background: Polymorphonuclear leucocytes are the first line of defence against foreign invaders and constitute the major cell type involved in certain types of acute and chronic inflammatory diseases. Aim of the Work: The aim of the present study was to investigate the changes in expression of BCL-2…
May 2015 DOI 10.14302/issn.2471-7061.jcrc-14-574
Rosalyn B. IrbyCorresponding author
Colon cancer has a five-year survival of 64.7%, and about 50,000 people are expected to die from colon cancer this year. Patients with metastatic colorectal cancer have a significantly worse prognosis, a 12.9% five-year survival. This emphasizes the need for strategies to inhibit the growth and meta…
May 2015 DOI 10.14302/issn.2574-4496.jtc-13-347
Emilio MevioCorresponding author
Primary thyroid leiomyosarcoma, is extremely rare, with only 19 cases reported in the literature to date. Onset of the tumor, which usually develops in only one lobe of the thyroid, is sudden and the tumor spreads rapidly to surrounding tissues. Preoperative differential diagnosis is extremely diffi…
Dec 2014 DOI 10.14302/issn.2326-0793.jpgr-14-598
Kim YC FungCorresponding author
Colorectal cancer is one of the most commonly diagnosed cancers worldwide and its prevalence can be reduced by changes to lifestyle and diet. Fermentation of dietary fibre by the gut microbiota and formation of short chain fatty acids, in particular butyrate, is widely thought to play a role in prev…
Feb 2014 DOI 10.14302/issn.2372-6601.jhor-13-346
Chloe E. ClaphamCorresponding author
Targeting cell metabolism is a therapeutic approach which has been used for the treatment of cancers with high levels of proliferation. Inhibition of metabolic processes in cancer cells has shown synergy with current therapeutic options to reduce refractory disease and relapse. In contrast, chronic…