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Apr 2020 DOI 10.14302/issn.2832-4048.jsm-20-3211
John PapaconstantinouCorresponding author
Aging mammalian skeletal muscle satellite cells (MuSCs) undergo a decline of stem cell/progenitor cell proliferative and regenerative capacity, and the development of a physiological milieu characteristic of a state of chronic sterile inflammation. p38αMAPK and ERK1/2 are two major signaling pathway…
Mar 2020 DOI 10.14302/issn.2691-8862.jvat-20-3275
Heidari AlirezaCorresponding author
Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA.
Coronavirus nanoparticles show a strong peak of Plasmon absorption in ultraviolet–visible zone. A strong interaction exists between the surface of Coronavirus nanoparticles and Bcr–Abl tyrosine–kinase inhibitors (TKI) such as Imatinib (STI571), Nilotinib (AMN107), Dasatinib (BMS–345825), Bosutinib (…
Feb 2020 DOI 10.14302/issn.2577-2279.ijha-20-3180
Ugochukwu UmeakuCorresponding author
Background Colon cancer is one of the leading causes of cancer death world-wide. There is a steady increase in incidence over the past four decades in developing countries. This has been partly attributed to increasingly low intake of vegetables among other causes. Aims Therefore this study aims to…
Aug 2019 DOI 10.14302/issn.2576-6694.jbbs-19-2953
Nida Syed Amber IlyasCorresponding author
Breast cancer has high incidence in women from both developed and developing countries. Approximately 2 million women are diagnosed with breast cancer in 2018. In Asia, unfortunately Pakistan leads the highest number of breast cancer patients. Various treatment strategies are present but they are no…
Jun 2019 DOI 10.14302/issn.2379-7835.ijn-19-2845
Jeremy J. JohnsonCorresponding author
The mangosteen fruit is a popular Southeast Asian fruit consumed for centuries. There have been a variety of xanthones isolated from the fruit, bark, roots and leaves with each having unique chemical and physical properties. Previously, the most abundant xanthone α-mangostin has been shown to inhibi…
May 2019 DOI 10.14302/issn.2328-0182.japst-19-2738
Aurore BARONCorresponding author
Rationale Prisons are major reservoirs of hepatitis C virus (HCV) in which a therapeutic approach has been particularly difficult so far. Prevalence of viral hepatitis C (HCV) is higher in prison environment in France than in the general population and is estimated to be 4,8%. The impact in prison e…
Apr 2019 DOI 10.14302/issn.2578-8590.ipj-19-2772
Francesco CrespiCorresponding author
Nociceptin/orphanin-FQ (NOCI) together with its receptor NOP are widely expressed in cortical and subcortical motor areas and it is known that NOCI acts as an anxiolytic attenuating the behavioral inhibition of animals acutely exposed to stressful/anxiogenic conditions. Influence of NOCI upon the do…
Apr 2019 DOI 10.14302/issn.2328-0182.japst-19-2759
Olov SternerCorresponding author
Cancer is the leading cause of death worldwide, and there is a constant need for new treatment strategies. Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as c…
Mar 2019 DOI 10.14302/issn.2471-2140.jaa-19-2699
Hassan M.M. MasoudCorresponding author
Xanthine oxidase is a commercially important enzyme with wide area of medical applications to develop diagnostic kits. Xanthine oxidase was extracted, purified and characterized from sheep liver (SLXO). The purification procedure involved acetone precipitation and chromatography on DEAE-cellulose an…
Feb 2019 DOI 10.14302/issn.2572-3030.jcgb-19-2581
Ashraf KhanCorresponding author
We report the case of a 75 year-old female with past history of ampullary adenocarcinoma presenting with a rapidly enlarging breast mass, initially misclassified on fine needle aspiration as a probable sarcoma, which was ultimately diagnosed as melanoma on resection in the absence of a known cutaneo…
Feb 2019 DOI 10.14302/issn.2574-612X.ijpr-18-2564
Prittesh PatelCorresponding author
The widely held belief that emotional and psychological processes affect our physical health, mental health and general well-being are central to a holistic view of the individual, and as such, it is a useful foundational concept in integrative medicine. The purpose of this paper is to review substa…
Feb 2019 DOI 10.14302/issn.2578-8590.ipj-19-2623
Jaime HinzpeterCorresponding author
Neosaxitoxin (NeoSTX) is a specific high-affinity inhibitor of voltage-dependent sodium channels, which has shown excellent results as a local anesthetic in various pathologies and post-operative protocols, since it effect is long-lasting and have virtually no side effects.The aim of this study was…
Jan 2019
Excessive variability in behavioral performance and neuronal activation is a common finding in studies of schizophrenia. Recent evidence suggests that this may be due to an imbalance in the ratio of excitation to inhibition in brain function, or E/I imbalance. We used computational modeling of visua…
Jan 2019 DOI 10.14302/issn.2639-3166.jar-18-2502
Michael CampbellCorresponding author
The compound 1,4-dimethylnaphthalene, originally isolated from dormant potatoes, is currently in use as a commercial sprout inhibitor. Growers and processors report a reduction in fungal infections in potatoes treated with DMN resulting in increased yields. To assess the effects of DMN on fungal gro…
Nov 2018 DOI 10.14302/issn.2689-5773.jcdp-18-2435
Anubha BajajCorresponding author
Theobjective of reviewing Hairy Cell Leukaemia may be achieved by emphasising the condition as a category of chronic lymphocytic leukaemia with hair like protrusions of the cytoplasm situated on the aberrant B cell surface. An infrequent disorder, hairy cell leukaemia contributes an estimated 2% of…
Oct 2018 DOI 10.14302/issn.2577-2279.ijha-18-2407
Hui FuCorresponding author
Oligodendrocytes are specialized glial cell in central nervous system (CNS) responsible for the formation of myelin sheath around the axon. Oligodendrocyte proliferation and differentiation is regulated by Wnt signaling pathway, at various stages. However, different study groups have described contr…
Aug 2018 DOI 10.14302/issn.2639-1716.jn-18-2208
Gerald J. MizejewskiCorresponding author
Breast cancer (BC) is the leading cause of cancer-related deaths in young to middle-aged women worldwide. Moreover, the survival rate in BC-patients is only 20% when associated with metastatic disease. The high mortality rate observed in BC women with metastatic disease has precipitated a major chal…
May 2018 DOI 10.14302/issn.2832-5311.jpcd-18-2077
Vladimír FarkašCorresponding author
Polysaccharide transglycosylases (PTGs) are a unique group of glycoside hydrolases playing important roles in the formation and modification of plant and fungal cell walls. Their action involves cutting the molecule of the polysaccharide substrate at the glycosidic bond, followed by transfer of the…
Nov 2017 DOI 10.14302/issn.2576-9383.jhhr-17-1768
Sahar Yassin IbrahimCorresponding author
Antifungal antagonism of different fourteen plant essential oils was examined as natural agents against economic and hygienic effective three yeasts; the preservative efficacy of most potent anti-yeast essential oil in food sanitary was also tested. Study involved oils antifungal bioactivity screeni…
Nov 2017 DOI 10.14302/issn.2372-6601.jhor-17-1761
Gitte Lee MortensenCorresponding author
With the introduction of tyrosine kinase inhibitors (TKI), patients with chronic myeloid leukemia (CML) have obtained survival rates close to normal. It may appear paradoxical, then, that medication adherence is suboptimal in some health care settings. As the first of its kind, this study aimed to e…