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Mar 2020 DOI 10.14302/issn.2766-8681.jcsr-21-3719
Bin ZhaoCorresponding author
Background Since receiving unexplained pneumonia patients at the Jinyintan Hospital in Wuhan, China in December 2019, the new coronavirus (COVID-19) has rapidly spread in Wuhan, China and spread to the entire China and some neighboring countries. We establish the dynamics model of infectious disease…
Jun 2019 DOI 10.14302/issn.2576-6694.jbbs-19-2784
Ernesto Cesar Pinto Leal-JuniorCorresponding author
The aim of this clinical study was to determine the efficacy of bilateral alternating somatosensory stimulation for the management of stress and anxiety during and after the Trier Social Stress Test (TSST), a laboratory procedure for reliably inducing stress in human subjects. For this, a randomized…
Feb 2019 DOI 10.14302/issn.2470-5020.jnrt-19-2618
Naiya PatelCorresponding author
Objective Testing a new drug, treatment, and medical device clinically is critically important before prescribing it to patient. Not determining the drug’s safety and efficacy through clinical trials might impose life threatening outcomes on its consumers. The research paper describes the critical f…
Aug 2018
Qifeng BaiCorresponding author
Drug design, referred to the fields of pharmacology, biotechnology and medicine, is in silico, in vitro and in vivo assay processes of finding new candidate medications based on the biological targets. The in silicoexperiments of drug discovery are involved in the macromolecular structure databases,…
Apr 2018
Dongye LiCorresponding author
Heart failure(HF) is a disease with high morbility and mortality. The benefits of current pharmacological and device therapy for survival outcomes of patients with HF are limited. Gene therapy represents a novel promising strategy in treating HF, as it can theoretically normalize the aberrantly expr…
Apr 2018
Antonio MolinoCorresponding author
The presence of bronchiectasis is considered an aggravating factor in COPD patients. In particular, the coexistence of bronchiectasis and COPD was associated with greater frequency and severity of exacerbations. The aim of this study is to investigate the impact of bronchiectasis in patients with CO…
Mar 2018 DOI 10.14302/issn.2642-9241.jrd-18-1958
Ba T TaCorresponding author
Military Hospital 103
Background Bronchoscopic lung volume reduction (BLVR) has been applied in COPD patients with heterogeneous emphysema. In this first clinical trial in Vietnam, we evaluated the safety and initial results of BLVR by one-way valve in COPD patients with severe emphysema. Methods We performed a prospecti…
Jul 2017 DOI 10.14302/issn.2574-4372.jesr-17-1705
Vijayalakshmi VarmaCorresponding author
Drug-induced cardiotoxicity is one of the predominant reasons for drug attrition and withdrawals. This is of critical concern when potentially cardiotoxic drugs are administered to individuals with inherited arrhythmogenic cardiac diseases or with metabolic diseases such as obesity and diabetes, whi…
Jul 2016 DOI 10.14302/issn.2574-4372.jesr-16-1055
Matthew B. JensenCorresponding author
Human-induced pluripotent stem cells (HiPSCs) demonstrate promise in their ability to differentiate into neural cells and ultimately replace the cell types and thereby brain tissue damaged by stroke. This may diminish cognitive impairment due to stroke. Prior to transplantation, an appropriate scaff…
Mar 2016 DOI 10.14302/issn.2470-5020.jnrt-15-800
Lili HuangCorresponding author
Although clinical trials in refractory epilepsy are currently carried out, the field of deep brain stimulation (DBS) in epilepsy is still at its initial stage. Little is known about where, when and how to stimulate and what would be the short and long consequences. Animal studies might provide clini…
Jan 2016 DOI 10.14302/issn.2470-5020.jnrt-15-803
Matthew B. JensenCorresponding author
We sought to identify early uses of blinding in therapeutic clinical trials of neurological disorders by multiple search methods. A 1784 report by Benjamin Franklin and others described the evaluation of the use of Mesmerism to treat neurological and other syndromes including headache and epilepsy,…
Jan 2014 DOI 10.14302/issn.2324-7339.jcrhap-13-edt.1.3
B. SharmaCorresponding author
This hypothesis‑driven review considers phytochemicals with putative anti‑HIV activity. It summarizes proposed mechanisms, in vitro evidence, and formulation issues, and calls for standardized assays and clinical trials to determine real‑world efficacy and safety.